Cargando…

Stabilizing mutations increase secretion of functional soluble TCR-Ig fusion proteins

BACKGROUND: Whereas T cell receptors (TCRs) detect peptide/major histocompatibility complexes (pMHCs) with exquisite specificity, there are challenges regarding their expression and use as soluble detection molecules due to molecular instability. We have investigated strategies for the production of...

Descripción completa

Detalles Bibliográficos
Autores principales:	Lunde, Elin, Løset, Geir Åge, Bogen, Bjarne, Sandlie, Inger
Formato:	Texto
Lenguaje:	English
Publicado:	BioMed Central 2010
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2936418/ https://www.ncbi.nlm.nih.gov/pubmed/20735812 http://dx.doi.org/10.1186/1472-6750-10-61

Ejemplares similares

Periplasmic expression of soluble single chain T cell receptors is rescued by the chaperone FkpA
por: Gunnarsen, Kristin S, et al.
Publicado: (2010)

Expanding the Versatility of Phage Display I: Efficient Display of Peptide-Tags on Protein VII of the Filamentous Phage
por: Løset, Geir Åge, et al.
Publicado: (2011)

Expanding the Versatility of Phage Display II: Improved Affinity Selection of Folded Domains on Protein VII and IX of the Filamentous Phage
por: Løset, Geir Åge, et al.
Publicado: (2011)

Targeting the MHC Ligandome by Use of TCR-Like Antibodies
por: Høydahl, Lene Støkken, et al.
Publicado: (2019)

Chaperone-assisted thermostability engineering of a soluble T cell receptor using phage display
por: Gunnarsen, Kristin S., et al.
Publicado: (2013)

Affinity maturation of TCR-like antibodies using phage display guided by structural modeling
por: Frick, Rahel, et al.
Publicado: (2022)

DeltaPhage—a novel helper phage for high-valence pIX phagemid display
por: Nilssen, Nicolay R., et al.
Publicado: (2012)

Phage Display Engineered T Cell Receptors as Tools for the Study of Tumor Peptide–MHC Interactions
por: Løset, Geir Åge, et al.
Publicado: (2015)

Soluble T-cell receptor design influences functional yield in an E. coli chaperone-assisted expression system
por: Gunnarsen, Kristin Støen, et al.
Publicado: (2018)

A Practical Approach to T-Cell Receptor Cloning and Expression
por: Wälchli, Sébastien, et al.
Publicado: (2011)

Targeted DNA vaccines for enhanced induction of idiotype-specific B and T cells
por: Fredriksen, Agnete B., et al.
Publicado: (2012)

B cell receptor ligation induces display of V-region peptides on MHC class II molecules to T cells
por: Huszthy, Peter Csaba, et al.
Publicado: (2019)

T Cell Recognition of the Dominant I-A(k)–Restricted Hen Egg Lysozyme Epitope: Critical Role for Asparagine Deamidation
por: McAdam, Stephen N., et al.
Publicado: (2001)

Increased Generation of HIV-1 gp120-Reactive CD8(+) T Cells by a DNA Vaccine Construct Encoding the Chemokine CCL3
por: Øynebråten, Inger, et al.
Publicado: (2014)

Design and Characterization of a New pVII Combinatorial Phage Display Peptide Library for Protease Substrate Mining Using Factor VII Activating Protease (FSAP) as Model
por: Kara, Emrah, et al.
Publicado: (2020)

Chimeric antigen receptor preparation from hybridoma to T-cell expression
por: Köksal, Hakan, et al.
Publicado: (2019)

Multivalent pIX phage display selects for distinct and improved antibody properties
por: Høydahl, Lene S., et al.
Publicado: (2016)

Characterization of human αβTCR repertoire and discovery of D-D fusion in TCRβ chains
por: Liu, Peipei, et al.
Publicado: (2014)

103 Modulation of Human Basophilic Responses by a Fibroleukin-Allergen Fusion Protein
por: Dooper, Maaike, et al.
Publicado: (2012)

Inhibition of endolysosome fusion increases exosome secretion
por: Shelke, Ganesh Vilas, et al.
Publicado: (2023)

Delayed Toxicity Associated with Soluble Anthrax Toxin Receptor Decoy-Ig Fusion Protein Treatment
por: Thomas, Diane, et al.
Publicado: (2012)

Endocytosis Deficient Murine Xcl1-Fusion Vaccine Enhances Protective Antibody Responses in Mice
por: Gudjonsson, Arnar, et al.
Publicado: (2019)

Lactobacillus plantarum displaying CCL3 chemokine in fusion with HIV-1 Gag derived antigen causes increased recruitment of T cells
por: Kuczkowska, Katarzyna, et al.
Publicado: (2015)

Upregulated TCRζ improves cytokine secretion in T cells from patients with AML
por: Chen, Shaohua, et al.
Publicado: (2015)

Extended plasma half-life of albumin-binding domain fused human IgA upon pH-dependent albumin engagement of human FcRn in vitro and in vivo
por: Mester, Simone, et al.
Publicado: (2021)

Increasing functional avidity of TCR-redirected T cells by removing defined N-glycosylation sites in the TCR constant domain
por: Kuball, Jürgen, et al.
Publicado: (2009)

Chronic TCR-MHC (self)-interactions limit the functional potential of TCR affinity-increased CD8 T lymphocytes
por: Duong, Minh Ngoc, et al.
Publicado: (2019)

DNA Vaccines: MHC II-Targeted Vaccine Protein Produced by Transfected Muscle Fibres Induces a Local Inflammatory Cell Infiltrate in Mice
por: Løvås, Tom-Ole, et al.
Publicado: (2014)

Dendritic cell targeted Ccl3- and Xcl1-fusion DNA vaccines differ in induced immune responses and optimal delivery site
por: Lysén, Anna, et al.
Publicado: (2019)

Pre-TCRα and TCRα Are Not Interchangeable Partners of TCRβ during T Lymphocyte Development
por: Borowski, Christine, et al.
Publicado: (2004)

Early molecular events induced by T cell receptor (TCR) signaling in immature CD4+ CD8+ thymocytes: increased synthesis of TCR-alpha protein is an early response to TCR signaling that compensates for TCR-alpha instability, improves TCR assembly, and parallels other indicators of positive selection
Publicado: (1995)

Author Correction: Dendritic cell targeted Ccl3- and Xcl1-fusion DNA vaccines differ in induced immune responses and optimal delivery site
por: Lysén, Anna, et al.
Publicado: (2020)

Engineered adenovirus fiber shaft fusion homotrimer of soluble TRAIL with enhanced stability and antitumor activity
por: Yan, J, et al.
Publicado: (2016)

Increased TCR signal strength in DN thymocytes promotes development of gut TCRαβ((+))CD8αα((+)) intraepithelial lymphocytes
por: Grandjean, Capucine L., et al.
Publicado: (2017)

Modifications outside CDR1, 2 and 3 of the TCR variable β domain increase TCR expression and antigen-specific function
por: Degirmencay, Abdullah, et al.
Publicado: (2023)

Cyclodextrin Complexation as a Way of Increasing the Aqueous Solubility and Stability of Carvedilol
por: Rigaud, Sébastien, et al.
Publicado: (2021)

Targeted DNA vaccines eliciting crossreactive anti-idiotypic antibody responses against human B cell malignancies in mice
por: Ruffini, Pier Adelchi, et al.
Publicado: (2014)

EuroClonality/BIOMED-2 guidelines for interpretation and reporting of Ig/TCR clonality testing in suspected lymphoproliferations
por: Langerak, A W, et al.
Publicado: (2012)

Serum trypsin and TCR as novel markers for predicting disease activity in IgG4-related disease
por: Fengqing, Wang, et al.
Publicado: (2014)

Coupling of HIV-1 Antigen to the Selective Autophagy Receptor SQSTM1/p62 Promotes T-Cell-Mediated Immunity
por: Andersen, Aram Nikolai, et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_2e0p4si72686idi6mvs6etc44k