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Preferential Re-Replication of Drosophila Heterochromatin in the Absence of Geminin

To ensure genomic integrity, the genome must be duplicated exactly once per cell cycle. Disruption of replication licensing mechanisms may lead to re-replication and genomic instability. Cdt1, also known as Double-parked (Dup) in Drosophila, is a key regulator of the assembly of the pre-replicative...

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Detalles Bibliográficos
Autores principales: Ding, Queying, MacAlpine, David M.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2936543/
https://www.ncbi.nlm.nih.gov/pubmed/20838463
http://dx.doi.org/10.1371/journal.pgen.1001112