Nucleo-Cytoplasmic Localization Domains Regulate Krüppel-Like Factor 6 (KLF6) Protein Stability and Tumor Suppressor Function

BACKGROUND: The tumor suppressor KLF6 and its oncogenic cytoplasmic splice variant KLF6-SV1 represent a paradigm in cancer biology in that their antagonistic cancer functions are encoded within the same gene. As a consequence of splicing, KLF6-SV1 loses both the C-terminus C(2)H(2) three zinc finger...

Descripción completa

Detalles Bibliográficos
Autores principales: Rodríguez, Estefanía, Aburjania, Nana, Priedigkeit, Nolan M., DiFeo, Analisa, Martignetti, John A.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2010
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2936564/
https://www.ncbi.nlm.nih.gov/pubmed/20844588
http://dx.doi.org/10.1371/journal.pone.0012639

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2936564/
https://www.ncbi.nlm.nih.gov/pubmed/20844588
http://dx.doi.org/10.1371/journal.pone.0012639

Ejemplares similares