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Nucleo-Cytoplasmic Localization Domains Regulate Krüppel-Like Factor 6 (KLF6) Protein Stability and Tumor Suppressor Function

BACKGROUND: The tumor suppressor KLF6 and its oncogenic cytoplasmic splice variant KLF6-SV1 represent a paradigm in cancer biology in that their antagonistic cancer functions are encoded within the same gene. As a consequence of splicing, KLF6-SV1 loses both the C-terminus C(2)H(2) three zinc finger...

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Detalles Bibliográficos
Autores principales:	Rodríguez, Estefanía, Aburjania, Nana, Priedigkeit, Nolan M., DiFeo, Analisa, Martignetti, John A.
Formato:	Texto
Lenguaje:	English
Publicado:	Public Library of Science 2010
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2936564/ https://www.ncbi.nlm.nih.gov/pubmed/20844588 http://dx.doi.org/10.1371/journal.pone.0012639

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