Gamma-secretase activating protein, a therapeutic target for Alzheimer's disease

Accumulation of neurotoxic βamyloid (Aβ) is a major hallmark of Alzheimer's disease (AD)1. Formation of Aβ is catalyzed by γsecretase, a protease with numerous substrates2,3. Little is known about the molecular mechanisms that confer substrate specificity on this potentially promiscuous enzyme....

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Detalles Bibliográficos
Autores principales: He, Gen, Luo, Wenjie, Li, Peng, Remmers, Christine, Netzer, William, Hendrick, Joseph, Bettayeb, Karima, Flajolet, Marc, Gorelick, Fred, Wennogle, Lawrence P., Greengard, Paul
Formato: Texto
Lenguaje:English
Publicado: 2010
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2936959/
https://www.ncbi.nlm.nih.gov/pubmed/20811458
http://dx.doi.org/10.1038/nature09325

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2936959/
https://www.ncbi.nlm.nih.gov/pubmed/20811458
http://dx.doi.org/10.1038/nature09325

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