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Gamma-secretase activating protein, a therapeutic target for Alzheimer's disease
Accumulation of neurotoxic βamyloid (Aβ) is a major hallmark of Alzheimer's disease (AD)1. Formation of Aβ is catalyzed by γsecretase, a protease with numerous substrates2,3. Little is known about the molecular mechanisms that confer substrate specificity on this potentially promiscuous enzyme....
| Autores principales: | , , , , , , , , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
2010
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2936959/ https://www.ncbi.nlm.nih.gov/pubmed/20811458 http://dx.doi.org/10.1038/nature09325 |