Alphavirus Replicon Particles Expressing TRP-2 Provide Potent Therapeutic Effect on Melanoma through Activation of Humoral and Cellular Immunity

BACKGROUND: Malignant melanoma is the deadliest form of skin cancer and is refractory to conventional chemotherapy and radiotherapy. Therefore alternative approaches to treat this disease, such as immunotherapy, are needed. Melanoma vaccine design has mainly focused on targeting CD8(+) T cells. Acti...

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Detalles Bibliográficos
Autores principales: Avogadri, Francesca, Merghoub, Taha, Maughan, Maureen F., Hirschhorn-Cymerman, Daniel, Morris, John, Ritter, Erika, Olmsted, Robert, Houghton, Alan N., Wolchok, Jedd D.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2010
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2937034/
https://www.ncbi.nlm.nih.gov/pubmed/20844763
http://dx.doi.org/10.1371/journal.pone.0012670

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2937034/
https://www.ncbi.nlm.nih.gov/pubmed/20844763
http://dx.doi.org/10.1371/journal.pone.0012670

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