Road blocks on paleogenomes—polymerase extension profiling reveals the frequency of blocking lesions in ancient DNA

Although the last few years have seen great progress in DNA sequence retrieval from fossil specimens, some of the characteristics of ancient DNA remain poorly understood. This is particularly true for blocking lesions, i.e. chemical alterations that cannot be bypassed by DNA polymerases and thus pre...

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Detalles Bibliográficos
Autores principales: Heyn, Patricia, Stenzel, Udo, Briggs, Adrian W., Kircher, Martin, Hofreiter, Michael, Meyer, Matthias
Formato: Texto
Lenguaje:English
Publicado: Oxford University Press 2010
Materias:
Methods Online
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2938203/
https://www.ncbi.nlm.nih.gov/pubmed/20587499
http://dx.doi.org/10.1093/nar/gkq572

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2938203/
https://www.ncbi.nlm.nih.gov/pubmed/20587499
http://dx.doi.org/10.1093/nar/gkq572

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