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Computational reprogramming of homing endonuclease specificity at multiple adjacent base pairs
Site-specific homing endonucleases are capable of inducing gene conversion via homologous recombination. Reprogramming their cleavage specificities allows the targeting of specific biological sites for gene correction or conversion. We used computational protein design to alter the cleavage specific...
| Autores principales: | , , , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
Oxford University Press
2010
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2938204/ https://www.ncbi.nlm.nih.gov/pubmed/20435674 http://dx.doi.org/10.1093/nar/gkq283 |