Regulation of Heparin-Binding EGF-Like Growth Factor by miR-212 and Acquired Cetuximab-Resistance in Head and Neck Squamous Cell Carcinoma

BACKGROUND: We hypothesized that chronic inhibition of epidermal growth factor receptor (EGFR) by cetuximab, a monoclonal anti-EGFR antibody, induces up-regulation of its ligands resulting in resistance and that microRNAs (miRs) play an important role in the ligand regulation in head and neck squamo...

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Detalles Bibliográficos
Autores principales: Hatakeyama, Hiromitsu, Cheng, Haixia, Wirth, Pamela, Counsell, Ashley, Marcrom, Samuel R., Wood, Carey Burton, Pohlmann, Paula R., Gilbert, Jill, Murphy, Barbara, Yarbrough, Wendell G., Wheeler, Deric L., Harari, Paul M., Guo, Yan, Shyr, Yu, Slebos, Robbert J., Chung, Christine H.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2010
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2938338/
https://www.ncbi.nlm.nih.gov/pubmed/20856931
http://dx.doi.org/10.1371/journal.pone.0012702

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2938338/
https://www.ncbi.nlm.nih.gov/pubmed/20856931
http://dx.doi.org/10.1371/journal.pone.0012702

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