Renal Dnase1 Enzyme Activity and Protein Expression Is Selectively Shut Down in Murine and Human Membranoproliferative Lupus Nephritis

BACKGROUND: Deposition of chromatin-IgG complexes within glomerular membranes is a key event in the pathogenesis of lupus nephritis. We recently reported an acquired loss of renal Dnase1 expression linked to transformation from mild to severe membranoproliferative lupus nephritis in (NZBxNZW)F1 mice...

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Detalles Bibliográficos
Autores principales: Zykova, Svetlana N., Tveita, Anders A., Rekvig, Ole Petter
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2010
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2938370/
https://www.ncbi.nlm.nih.gov/pubmed/20856893
http://dx.doi.org/10.1371/journal.pone.0012096

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2938370/
https://www.ncbi.nlm.nih.gov/pubmed/20856893
http://dx.doi.org/10.1371/journal.pone.0012096

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