Structural Biology of DNA Repair: Spatial Organisation of the Multicomponent Complexes of Nonhomologous End Joining

Nonhomologous end joining (NHEJ) plays a major role in double-strand break DNA repair, which involves a series of steps mediated by multiprotein complexes. A ring-shaped Ku70/Ku80 heterodimer forms first at broken DNA ends, DNA-dependent protein kinase catalytic subunit (DNA-PKcs) binds to mediate s...

Descripción completa

Detalles Bibliográficos
Autores principales: Ochi, Takashi, Sibanda, Bancinyane Lynn, Wu, Qian, Chirgadze, Dimitri Y., Bolanos-Garcia, Victor M., Blundell, Tom L.
Formato: Texto
Lenguaje:English
Publicado: SAGE-Hindawi Access to Research 2010
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2938450/
https://www.ncbi.nlm.nih.gov/pubmed/20862368
http://dx.doi.org/10.4061/2010/621695

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2938450/
https://www.ncbi.nlm.nih.gov/pubmed/20862368
http://dx.doi.org/10.4061/2010/621695

Ejemplares similares