Active Site Conformational Dynamics in Human Uridine Phosphorylase 1

Uridine phosphorylase (UPP) is a central enzyme in the pyrimidine salvage pathway, catalyzing the reversible phosphorolysis of uridine to uracil and ribose-1-phosphate. Human UPP activity has been a focus of cancer research due to its role in activating fluoropyrimidine nucleoside chemotherapeutic a...

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Detalles Bibliográficos
Autores principales: Roosild, Tarmo P., Castronovo, Samantha
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2010
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2939078/
https://www.ncbi.nlm.nih.gov/pubmed/20856879
http://dx.doi.org/10.1371/journal.pone.0012741

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2939078/
https://www.ncbi.nlm.nih.gov/pubmed/20856879
http://dx.doi.org/10.1371/journal.pone.0012741

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