In vivo quantification of formulated and chemically modified small interfering RNA by heating-in-Triton quantitative reverse transcription polymerase chain reaction (HIT qRT-PCR)

BACKGROUND: While increasing numbers of small interfering RNA (siRNA) therapeutics enter into clinical trials, the quantification of siRNA from clinical samples for pharmacokinetic studies remains a challenge. This challenge is even more acute for the quantification of chemically modified and formul...

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Detalles Bibliográficos
Autores principales: Landesman, Yosef, Svrzikapa, Nenad, Cognetta, Armand, Zhang, Xuemei, Bettencourt, Brian R, Kuchimanchi, Satya, Dufault, Keri, Shaikh, Sarfraz, Gioia, Maple, Akinc, Akin, Hutabarat, Renta, Meyers, Rachel
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2010
Materias:
Methodology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2939650/
https://www.ncbi.nlm.nih.gov/pubmed/20731861
http://dx.doi.org/10.1186/1758-907X-1-16

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2939650/
https://www.ncbi.nlm.nih.gov/pubmed/20731861
http://dx.doi.org/10.1186/1758-907X-1-16

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