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Upregulation of synaptotagmin IV inhibits transmitter release in PC12 cells with targeted synaptotagmin I knockdown

BACKGROUND: The function of synaptotagmins (syt) in Ca(2+)-dependent transmitter release has been attributed primarily to Ca(2+)-dependent isoforms such as syt I. Recently, syt IV, an inducible Ca(2+)-independent isoform has been implicated in transmitter release. We postulated that the effects of s...

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Detalles Bibliográficos
Autores principales: Moore-Dotson, Johnnie M, Papke, Jason B, Harkins, Amy B
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2939654/
https://www.ncbi.nlm.nih.gov/pubmed/20735850
http://dx.doi.org/10.1186/1471-2202-11-104