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Correlated Mutations: A Hallmark of Phenotypic Amino Acid Substitutions

Point mutations resulting in the substitution of a single amino acid can cause severe functional consequences, but can also be completely harmless. Understanding what determines the phenotypical impact is important both for planning targeted mutation experiments in the laboratory and for analyzing n...

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Detalles Bibliográficos
Autores principales: Kowarsch, Andreas, Fuchs, Angelika, Frishman, Dmitrij, Pagel, Philipp
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2940720/
https://www.ncbi.nlm.nih.gov/pubmed/20862353
http://dx.doi.org/10.1371/journal.pcbi.1000923