Rescue of HIV-1 Release by Targeting Widely Divergent NEDD4-Type Ubiquitin Ligases and Isolated Catalytic HECT Domains to Gag

Retroviruses engage the ESCRT pathway through late assembly (L) domains in Gag to promote virus release. HIV-1 uses a PTAP motif as its primary L domain, which interacts with the ESCRT-I component Tsg101. In contrast, certain other retroviruses primarily use PPxY-type L domains, which constitute lig...

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Detalles Bibliográficos
Autores principales: Weiss, Eric R., Popova, Elena, Yamanaka, Hikaru, Kim, Hyung Cheol, Huibregtse, Jon M., Göttlinger, Heinrich
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2010
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2940739/
https://www.ncbi.nlm.nih.gov/pubmed/20862313
http://dx.doi.org/10.1371/journal.ppat.1001107

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2940739/
https://www.ncbi.nlm.nih.gov/pubmed/20862313
http://dx.doi.org/10.1371/journal.ppat.1001107

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