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Differentiation in Neuroblastoma: Diffusion-Limited Hypoxia Induces Neuro-Endocrine Secretory Protein 55 and Other Markers of a Chromaffin Phenotype

BACKGROUND: Neuroblastoma is a childhood malignancy of sympathetic embryonal origin. A high potential for differentiation is a hallmark of neuroblastoma cells. We have previously presented data to suggest that in situ differentiation in tumors frequently proceeds along the chromaffin lineage and tha...

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Detalles Bibliográficos
Autores principales: Hedborg, Fredrik, Fischer-Colbrie, Reiner, Östlin, Nurtena, Sandstedt, Bengt, Tran, Maxine G. B., Maxwell, Patrick H.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2941466/
https://www.ncbi.nlm.nih.gov/pubmed/20862257
http://dx.doi.org/10.1371/journal.pone.0012825