Phosphorylation regulates proteasomal-mediated degradation and solubility of TAR DNA binding protein-43 C-terminal fragments

BACKGROUND: Inclusions of TAR DNA binding protein-43 (TDP-43) are the defining histopathological feature of several neurodegenerative diseases collectively referred to as TDP-43 proteinopathies. These diseases are characterized by the presence of cellular aggregates composed of abnormally phosphoryl...

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Detalles Bibliográficos
Autores principales: Zhang, Yong-Jie, Gendron, Tania F, Xu, Ya-Fei, Ko, Li-Wen, Yen, Shu-Hui, Petrucelli, Leonard
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2010
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2941488/
https://www.ncbi.nlm.nih.gov/pubmed/20804554
http://dx.doi.org/10.1186/1750-1326-5-33

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2941488/
https://www.ncbi.nlm.nih.gov/pubmed/20804554
http://dx.doi.org/10.1186/1750-1326-5-33

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