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Phosphorylation regulates proteasomal-mediated degradation and solubility of TAR DNA binding protein-43 C-terminal fragments

BACKGROUND: Inclusions of TAR DNA binding protein-43 (TDP-43) are the defining histopathological feature of several neurodegenerative diseases collectively referred to as TDP-43 proteinopathies. These diseases are characterized by the presence of cellular aggregates composed of abnormally phosphoryl...

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Detalles Bibliográficos
Autores principales:	Zhang, Yong-Jie, Gendron, Tania F, Xu, Ya-Fei, Ko, Li-Wen, Yen, Shu-Hui, Petrucelli, Leonard
Formato:	Texto
Lenguaje:	English
Publicado:	BioMed Central 2010
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2941488/ https://www.ncbi.nlm.nih.gov/pubmed/20804554 http://dx.doi.org/10.1186/1750-1326-5-33

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