The small molecule specific EphB4 kinase inhibitor NVP-BHG712 inhibits VEGF driven angiogenesis

EphB4 and its cognitive ligand ephrinB2 play an important role in embryonic vessel development and vascular remodeling. In addition, several reports suggest that this receptor ligand pair is also involved in pathologic vessel formation in adults including tumor angiogenesis. Eph/ephrin signaling is...

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Detalles Bibliográficos
Autores principales: Martiny-Baron, Georg, Holzer, Philipp, Billy, Eric, Schnell, Christian, Brueggen, Joseph, Ferretti, Mireille, Schmiedeberg, Niko, Wood, Jeanette M., Furet, Pascal, Imbach, Patricia
Formato: Texto
Lenguaje:English
Publicado: Springer Netherlands 2010
Materias:
Original Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2941628/
https://www.ncbi.nlm.nih.gov/pubmed/20803239
http://dx.doi.org/10.1007/s10456-010-9183-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2941628/
https://www.ncbi.nlm.nih.gov/pubmed/20803239
http://dx.doi.org/10.1007/s10456-010-9183-z

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