Mutations in matrix and SP1 repair the packaging specificity of a Human Immunodeficiency Virus Type 1 mutant by reducing the association of Gag with spliced viral RNA

BACKGROUND: The viral genome of HIV-1 contains several secondary structures that are important for regulating viral replication. The stem-loop 1 (SL1) sequence in the 5' untranslated region directs HIV-1 genomic RNA dimerization and packaging into the virion. Without SL1, HIV-1 cannot replicate...

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Detalles Bibliográficos
Autores principales: Ristic, Natalia, Chin, Mario PS
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2010
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2941742/
https://www.ncbi.nlm.nih.gov/pubmed/20825656
http://dx.doi.org/10.1186/1742-4690-7-73

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2941742/
https://www.ncbi.nlm.nih.gov/pubmed/20825656
http://dx.doi.org/10.1186/1742-4690-7-73

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