Functional characterization of the protein C A267T mutation: evidence for impaired secretion due to defective intracellular transport

BACKGROUND: Activated protein C (PC) is a serine protease that regulates blood coagulation by inactivating coagulation factors Va and VIIIa. PC deficiency is an autosomally inherited disorder associated with a high risk of recurrent venous thrombosis. The aim of the study was to explore the mechanis...

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Detalles Bibliográficos
Autores principales: Tjeldhorn, Lena, Iversen, Nina, Sandvig, Kirsten, Bergan, Jonas, Sandset, Per Morten, Skretting, Grethe
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2010
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2942808/
https://www.ncbi.nlm.nih.gov/pubmed/20815936
http://dx.doi.org/10.1186/1471-2121-11-67

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2942808/
https://www.ncbi.nlm.nih.gov/pubmed/20815936
http://dx.doi.org/10.1186/1471-2121-11-67

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