Genome instability due to ribonucleotide incorporation into DNA

Maintaining the chemical identity of DNA depends on ribonucleotide exclusion by DNA polymerases. However, ribonucleotide exclusion during DNA synthesis in vitro is imperfect. To determine if ribonucleotides are incorporated during DNA replication in vivo, we substituted leucine or glycine for an act...

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Detalles Bibliográficos
Autores principales: Nick McElhinny, Stephanie A., Kumar, Dinesh, Clark, Alan B., Watt, Danielle L., Watts, Brian E., Lundström, Else-Britt, Johansson, Erik, Chabes, Andrei, Kunkel, Thomas A.
Formato: Texto
Lenguaje:English
Publicado: 2010
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2942972/
https://www.ncbi.nlm.nih.gov/pubmed/20729855
http://dx.doi.org/10.1038/nchembio.424

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2942972/
https://www.ncbi.nlm.nih.gov/pubmed/20729855
http://dx.doi.org/10.1038/nchembio.424

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