Cholesterol Pathways Affected by Small Molecules That Decrease Sterol Levels in Niemann-Pick Type C Mutant Cells

BACKGROUND: Niemann-Pick type C (NPC) disease is a genetically inherited multi-lipid storage disorder with impaired efflux of cholesterol from lysosomal storage organelles. METHODOLOGY/PRINCIPAL FINDINGS: The effect of screen-selected cholesterol lowering compounds on the major sterol pathways was s...

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Detalles Bibliográficos
Autores principales: Rujoi, Madalina, Pipalia, Nina H., Maxfield, Frederick R.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2010
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2943465/
https://www.ncbi.nlm.nih.gov/pubmed/20877719
http://dx.doi.org/10.1371/journal.pone.0012788

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2943465/
https://www.ncbi.nlm.nih.gov/pubmed/20877719
http://dx.doi.org/10.1371/journal.pone.0012788

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