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Cholesterol Pathways Affected by Small Molecules That Decrease Sterol Levels in Niemann-Pick Type C Mutant Cells

BACKGROUND: Niemann-Pick type C (NPC) disease is a genetically inherited multi-lipid storage disorder with impaired efflux of cholesterol from lysosomal storage organelles. METHODOLOGY/PRINCIPAL FINDINGS: The effect of screen-selected cholesterol lowering compounds on the major sterol pathways was s...

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Detalles Bibliográficos
Autores principales:	Rujoi, Madalina, Pipalia, Nina H., Maxfield, Frederick R.
Formato:	Texto
Lenguaje:	English
Publicado:	Public Library of Science 2010
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2943465/ https://www.ncbi.nlm.nih.gov/pubmed/20877719 http://dx.doi.org/10.1371/journal.pone.0012788

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