Complement-mediated regulation of the interleukin 17A axis is a central genetic determinant of the severity of experimental allergic asthma

Severe asthma is associated with interleukin 17A (IL-17A) production. The exact role of IL-17A in severe asthma and the factors driving its production are unknown. Here we have demonstrated that IL-17A mediated severe airway hyperresponsiveness (AHR) in susceptible strains of mice by enhancing IL-13...

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Detalles Bibliográficos
Autores principales: Lajoie, Stephane, Lewkowich, Ian P., Suzuki, Yusuke, Clark, Jennifer R., Sproles, Alyssa A., Dienger, Krista, Budelsky, Alison L., Wills-Karp, Marsha
Formato: Texto
Lenguaje:English
Publicado: 2010
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2943538/
https://www.ncbi.nlm.nih.gov/pubmed/20802484
http://dx.doi.org/10.1038/ni.1926

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2943538/
https://www.ncbi.nlm.nih.gov/pubmed/20802484
http://dx.doi.org/10.1038/ni.1926

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