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Complement-mediated regulation of the interleukin 17A axis is a central genetic determinant of the severity of experimental allergic asthma
Severe asthma is associated with interleukin 17A (IL-17A) production. The exact role of IL-17A in severe asthma and the factors driving its production are unknown. Here we have demonstrated that IL-17A mediated severe airway hyperresponsiveness (AHR) in susceptible strains of mice by enhancing IL-13...
| Autores principales: | , , , , , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
2010
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2943538/ https://www.ncbi.nlm.nih.gov/pubmed/20802484 http://dx.doi.org/10.1038/ni.1926 |