Incorporation of pseudouridine into mRNA enhances translation by diminishing PKR activation

Previous studies have shown that the translation level of in vitro transcribed messenger RNA (mRNA) is enhanced when its uridines are replaced with pseudouridines; however, the reason for this enhancement has not been identified. Here, we demonstrate that in vitro transcripts containing uridine acti...

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Detalles Bibliográficos
Autores principales: Anderson, Bart R., Muramatsu, Hiromi, Nallagatla, Subba R., Bevilacqua, Philip C., Sansing, Lauren H., Weissman, Drew, Karikó, Katalin
Formato: Texto
Lenguaje:English
Publicado: Oxford University Press 2010
Materias:
RNA
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2943593/
https://www.ncbi.nlm.nih.gov/pubmed/20457754
http://dx.doi.org/10.1093/nar/gkq347

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2943593/
https://www.ncbi.nlm.nih.gov/pubmed/20457754
http://dx.doi.org/10.1093/nar/gkq347

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