Synthesis-dependent microhomology-mediated end joining accounts for multiple types of repair junctions

Ku or DNA ligase 4-independent alternative end joining (alt-EJ) repair of DNA double-strand breaks (DSBs) frequently correlates with increased junctional microhomology. However, alt-EJ also produces junctions without microhomology (apparent blunt joins), and the exact role of microhomology in both a...

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Detalles Bibliográficos
Autores principales: Yu, Amy Marie, McVey, Mitch
Formato: Texto
Lenguaje:English
Publicado: Oxford University Press 2010
Materias:
Genome Integrity, Repair and Replication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2943611/
https://www.ncbi.nlm.nih.gov/pubmed/20460465
http://dx.doi.org/10.1093/nar/gkq379

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2943611/
https://www.ncbi.nlm.nih.gov/pubmed/20460465
http://dx.doi.org/10.1093/nar/gkq379

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