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A calcineurin/AKAP complex is required for NMDA receptor-dependent LTD

AKAP79/150 is a protein scaffold thought to position specific kinases (PKA, PKC) and phosphastases (calcineurin) in appropriate synaptic domains so that their activities can regulate excitatory synaptic strength. Using a viral-mediated molecular replacement strategy in rat hippocampal slices, we fou...

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Detalles Bibliográficos
Autores principales: Jurado, Sandra, Biou, Virginie, Malenka, Robert C.
Formato: Texto
Lenguaje:English
Publicado: 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2943866/
https://www.ncbi.nlm.nih.gov/pubmed/20694001
http://dx.doi.org/10.1038/nn.2613