A calcineurin/AKAP complex is required for NMDA receptor-dependent LTD

AKAP79/150 is a protein scaffold thought to position specific kinases (PKA, PKC) and phosphastases (calcineurin) in appropriate synaptic domains so that their activities can regulate excitatory synaptic strength. Using a viral-mediated molecular replacement strategy in rat hippocampal slices, we fou...

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Detalles Bibliográficos
Autores principales: Jurado, Sandra, Biou, Virginie, Malenka, Robert C.
Formato: Texto
Lenguaje:English
Publicado: 2010
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2943866/
https://www.ncbi.nlm.nih.gov/pubmed/20694001
http://dx.doi.org/10.1038/nn.2613
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author Jurado, Sandra
Biou, Virginie
Malenka, Robert C.
author_facet Jurado, Sandra
Biou, Virginie
Malenka, Robert C.
author_sort Jurado, Sandra
collection PubMed
description AKAP79/150 is a protein scaffold thought to position specific kinases (PKA, PKC) and phosphastases (calcineurin) in appropriate synaptic domains so that their activities can regulate excitatory synaptic strength. Using a viral-mediated molecular replacement strategy in rat hippocampal slices, we found that AKAP is required for NMDA receptor-dependent LTD solely due to its interaction with calcineurin.
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spelling pubmed-29438662011-03-01 A calcineurin/AKAP complex is required for NMDA receptor-dependent LTD Jurado, Sandra Biou, Virginie Malenka, Robert C. Nat Neurosci Article AKAP79/150 is a protein scaffold thought to position specific kinases (PKA, PKC) and phosphastases (calcineurin) in appropriate synaptic domains so that their activities can regulate excitatory synaptic strength. Using a viral-mediated molecular replacement strategy in rat hippocampal slices, we found that AKAP is required for NMDA receptor-dependent LTD solely due to its interaction with calcineurin. 2010-08-08 2010-09 /pmc/articles/PMC2943866/ /pubmed/20694001 http://dx.doi.org/10.1038/nn.2613 Text en Users may view, print, copy, download and text and data- mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use: http://www.nature.com/authors/editorial_policies/license.html#terms
spellingShingle Article
Jurado, Sandra
Biou, Virginie
Malenka, Robert C.
A calcineurin/AKAP complex is required for NMDA receptor-dependent LTD
title A calcineurin/AKAP complex is required for NMDA receptor-dependent LTD
title_full A calcineurin/AKAP complex is required for NMDA receptor-dependent LTD
title_fullStr A calcineurin/AKAP complex is required for NMDA receptor-dependent LTD
title_full_unstemmed A calcineurin/AKAP complex is required for NMDA receptor-dependent LTD
title_short A calcineurin/AKAP complex is required for NMDA receptor-dependent LTD
title_sort calcineurin/akap complex is required for nmda receptor-dependent ltd
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2943866/
https://www.ncbi.nlm.nih.gov/pubmed/20694001
http://dx.doi.org/10.1038/nn.2613
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