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Cathepsin L Inhibition Prevents Murine Autoimmune Diabetes via Suppression of CD8(+) T Cell Activity
BACKGROUND: Type 1 diabetes (T1D) is an autoimmune disease resulting from defects in central and peripheral tolerance and characterized by T cell-mediated destruction of islet β cells. To determine whether specific lysosomal proteases might influence the outcome of a T cell–mediated autoimmune respo...
| Autores principales: | , , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2010
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2943924/ https://www.ncbi.nlm.nih.gov/pubmed/20877570 http://dx.doi.org/10.1371/journal.pone.0012894 |