Light Chain Separated from the Rest of the Type A Botulinum Neurotoxin Molecule Is the Most Catalytically Active Form

Botulinum neurotoxins (BoNT) are the most potent of all toxins. The 50 kDa N-terminal endopeptidase catalytic light chain (LC) of BoNT is located next to its central, putative translocation domain. After binding to the peripheral neurons, the central domain of BoNT helps the LC translocate into cyto...

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Detalles Bibliográficos
Autores principales: Gul, Nizamettin, Smith, Leonard A., Ahmed, S. Ashraf
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2010
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2943925/
https://www.ncbi.nlm.nih.gov/pubmed/20877571
http://dx.doi.org/10.1371/journal.pone.0012872

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2943925/
https://www.ncbi.nlm.nih.gov/pubmed/20877571
http://dx.doi.org/10.1371/journal.pone.0012872

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