p53 Plays an Important Role in Cell Fate Determination after Exposure to Microcystin-LR

BACKGROUND: Microcystin-LR, a cyclic heptapeptide, possesses the ability to inhibit the serine/threonine protein phosphatases PP1 and PP2A and, consequently, exhibits acute hepatocytotoxicity. Moreover, microcystin-LR induces cellular proliferation, resulting in tumor-promoting activity in hepatocyt...

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Detalles Bibliográficos
Autores principales: Takumi, Shota, Komatsu, Masaharu, Furukawa, Tatsuhiko, Ikeda, Ryuji, Sumizawa, Tomoyuki, Akenaga, Hitomi, Maeda, Yuta, Aoyama, Kohji, Arizono, Koji, Ando, Seiichi, Takeuchi, Toru
Formato: Texto
Lenguaje:English
Publicado: National Institute of Environmental Health Sciences 2010
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2944092/
https://www.ncbi.nlm.nih.gov/pubmed/20421190
http://dx.doi.org/10.1289/ehp.1001899

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2944092/
https://www.ncbi.nlm.nih.gov/pubmed/20421190
http://dx.doi.org/10.1289/ehp.1001899

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