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Substitution of adeno-associated virus Rep protein binding and nicking sites with human Chromosome 19 sequences
BACKGROUND: Adeno-associated virus type 2 (AAV2) preferentially integrates its DNA at a ~2 kb region of human chromosome 19, designated AAVS1 (also known as MBS85). Integration at AAVS1 requires the AAV2 replication (Rep) proteins and a DNA sequence within AAVS1 containing a 16 bp Rep recognition se...
| Autores principales: | , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
BioMed Central
2010
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2944168/ https://www.ncbi.nlm.nih.gov/pubmed/20825662 http://dx.doi.org/10.1186/1743-422X-7-218 |