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Engineering the Redox Potential over a Wide Range within a New Class of FeS Proteins

[Image: see text] MitoNEET is a newly discovered mitochondrial protein and a target of the TZD class of antidiabetes drugs. MitoNEET is homodimeric with each protomer binding a [2Fe-2S] center through a rare 3-Cys and 1-His coordination geometry. Both the fold and the coordination of the [2Fe-2S] ce...

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Detalles Bibliográficos
Autores principales: Zuris, John A., Halim, Danny A., Conlan, Andrea R., Abresch, Edward C., Nechushtai, Rachel, Paddock, Mark L., Jennings, Patricia A.
Formato: Texto
Lenguaje:English
Publicado: American Chemical Society 2010
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2944382/
https://www.ncbi.nlm.nih.gov/pubmed/20812736
http://dx.doi.org/10.1021/ja103920k