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Experimental and Computational Analysis of Polyglutamine-Mediated Cytotoxicity
Expanded polyglutamine (polyQ) proteins are known to be the causative agents of a number of human neurodegenerative diseases but the molecular basis of their cytoxicity is still poorly understood. PolyQ tracts may impede the activity of the proteasome, and evidence from single cell imaging suggests...
| Autores principales: | , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2010
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2944785/ https://www.ncbi.nlm.nih.gov/pubmed/20885783 http://dx.doi.org/10.1371/journal.pcbi.1000944 |