GPR54 Regulates ERK1/2 Activity and Hypothalamic Gene Expression in a Gα(q/11) and β-Arrestin-Dependent Manner

G protein-coupled receptor 54 (GPR54) is a G(q/11)-coupled 7 transmembrane-spanning receptor (7TMR). Activation of GPR54 by kisspeptin (Kp) stimulates PIP(2) hydrolysis, Ca(2+) mobilization and ERK1/2 MAPK phosphorylation. Kp and GPR54 are established regulators of the hypothalamic-pituitary-gonadal...

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Detalles Bibliográficos
Autores principales: Szereszewski, Jacob M., Pampillo, Macarena, Ahow, Maryse R., Offermanns, Stefan, Bhattacharya, Moshmi, Babwah, Andy V.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2010
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2944883/
https://www.ncbi.nlm.nih.gov/pubmed/20886089
http://dx.doi.org/10.1371/journal.pone.0012964

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2944883/
https://www.ncbi.nlm.nih.gov/pubmed/20886089
http://dx.doi.org/10.1371/journal.pone.0012964

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