H1047R phosphatidylinositol 3-kinase mutant enhances HER2-mediated transformation via heregulin production and activation of HER3

Hyperactivation of phosphatidylinositol-3 kinase (PI3K) can occur as a result of somatic mutations in PIK3CA, the gene encoding the p110α subunit of PI3K. The HER2 oncogene is amplified in 25% of all breast cancers and some of these tumors also harbor PIK3CA mutations. We examined mechanisms by whic...

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Detalles Bibliográficos
Autores principales: Chakrabarty, Anindita, Rexer, Brent N., Wang, Shizhen Emily, Cook, Rebecca S., Engelman, Jeffrey A., Arteaga, Carlos, L.
Formato: Texto
Lenguaje:English
Publicado: 2010
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2945381/
https://www.ncbi.nlm.nih.gov/pubmed/20581867
http://dx.doi.org/10.1038/onc.2010.257

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2945381/
https://www.ncbi.nlm.nih.gov/pubmed/20581867
http://dx.doi.org/10.1038/onc.2010.257

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