In acute myeloid leukemia, B7-H1 (PD-L1) protection of blasts from cytotoxic T cells is induced by TLR ligands and interferon-gamma and can be reversed using MEK inhibitors

B7-H1 (PD-L1) is a B7-related protein that inhibits T-cell responses. B7-H1 participates in the immunoescape of cancer cells and is also involved in the long-term persistence of leukemic cells in a mouse model of leukemia. B7-H1 can be constitutively expressed by cancer cells, but is also induced by...

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Detalles Bibliográficos
Autores principales: Berthon, Céline, Driss, Virginie, Liu, Jizhong, Kuranda, Klaudia, Leleu, Xavier, Jouy, Nathalie, Hetuin, Dominique, Quesnel, Bruno
Formato: Texto
Lenguaje:English
Publicado: Springer-Verlag 2010
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2945474/
https://www.ncbi.nlm.nih.gov/pubmed/20814675
http://dx.doi.org/10.1007/s00262-010-0909-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2945474/
https://www.ncbi.nlm.nih.gov/pubmed/20814675
http://dx.doi.org/10.1007/s00262-010-0909-y

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