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Targeting Toll-Like Receptors for Treatment of SLE
Toll-like receptors (TLRs) are important innate immune receptors for the identification and clearance of invading pathogens. Twelve TLRs that recognize various conserved components of microorganisms are currently known. Among these, the endosomal TLRs 3, 7/8, and 9 recognize dsRNA, ssRNA, and CpG DN...
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Formato: | Texto |
Lenguaje: | English |
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Hindawi Publishing Corporation
2010
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2945668/ https://www.ncbi.nlm.nih.gov/pubmed/20886024 http://dx.doi.org/10.1155/2010/498980 |
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author | Horton, Christopher G. Pan, Zi-jian Farris, A. Darise |
author_facet | Horton, Christopher G. Pan, Zi-jian Farris, A. Darise |
author_sort | Horton, Christopher G. |
collection | PubMed |
description | Toll-like receptors (TLRs) are important innate immune receptors for the identification and clearance of invading pathogens. Twelve TLRs that recognize various conserved components of microorganisms are currently known. Among these, the endosomal TLRs 3, 7/8, and 9 recognize dsRNA, ssRNA, and CpG DNA, respectively. Nucleic acid-sensing TLRs, TLR 7 in particular, have been implicated in systemic lupus erythematosus (SLE) and are thought to exacerbate disease pathology. Activation of these TLRs results in the production of inflammatory cytokines and type I interferon. Genome-wide association studies, single nucleotide polymorphism analyses as well as experimental mouse models have provided evidence of TLR signaling involvement in SLE and other autoimmune diseases. Since activation of these receptor pathways promotes autoimmune phenotypes, inhibitory drugs that target these pathways constitute important new therapeutic strategies for the treatment of systemic autoimmunity. |
format | Text |
id | pubmed-2945668 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2010 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-29456682010-09-30 Targeting Toll-Like Receptors for Treatment of SLE Horton, Christopher G. Pan, Zi-jian Farris, A. Darise Mediators Inflamm Review Article Toll-like receptors (TLRs) are important innate immune receptors for the identification and clearance of invading pathogens. Twelve TLRs that recognize various conserved components of microorganisms are currently known. Among these, the endosomal TLRs 3, 7/8, and 9 recognize dsRNA, ssRNA, and CpG DNA, respectively. Nucleic acid-sensing TLRs, TLR 7 in particular, have been implicated in systemic lupus erythematosus (SLE) and are thought to exacerbate disease pathology. Activation of these TLRs results in the production of inflammatory cytokines and type I interferon. Genome-wide association studies, single nucleotide polymorphism analyses as well as experimental mouse models have provided evidence of TLR signaling involvement in SLE and other autoimmune diseases. Since activation of these receptor pathways promotes autoimmune phenotypes, inhibitory drugs that target these pathways constitute important new therapeutic strategies for the treatment of systemic autoimmunity. Hindawi Publishing Corporation 2010 2010-09-19 /pmc/articles/PMC2945668/ /pubmed/20886024 http://dx.doi.org/10.1155/2010/498980 Text en Copyright © 2010 Christopher G. Horton et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Horton, Christopher G. Pan, Zi-jian Farris, A. Darise Targeting Toll-Like Receptors for Treatment of SLE |
title | Targeting Toll-Like Receptors for Treatment of SLE |
title_full | Targeting Toll-Like Receptors for Treatment of SLE |
title_fullStr | Targeting Toll-Like Receptors for Treatment of SLE |
title_full_unstemmed | Targeting Toll-Like Receptors for Treatment of SLE |
title_short | Targeting Toll-Like Receptors for Treatment of SLE |
title_sort | targeting toll-like receptors for treatment of sle |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2945668/ https://www.ncbi.nlm.nih.gov/pubmed/20886024 http://dx.doi.org/10.1155/2010/498980 |
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