Effect of N3-Methyladenine and an Isosteric Stable Analogue on DNA Polymerization

N3-methyladenine (3-mA) is a cytotoxic lesion formed by the reaction of DNA with many methylating agents, including antineoplastic drugs, environmental agents and endogenously generated compounds. The toxicity of 3-mA has been attributed to its ability to block DNA polymerization. Using Me-lex, a co...

Descripción completa

Detalles Bibliográficos
Autores principales: Settles, Samuel, Wang, Ruo-Wen, Fronza, Gilberto, Gold, Barry
Formato: Texto
Lenguaje:English
Publicado: SAGE-Hindawi Access to Research 2010
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2945674/
https://www.ncbi.nlm.nih.gov/pubmed/20936169
http://dx.doi.org/10.4061/2010/426505

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2945674/
https://www.ncbi.nlm.nih.gov/pubmed/20936169
http://dx.doi.org/10.4061/2010/426505

Ejemplares similares