Architecture of Y-Family DNA Polymerases Relevant to Translesion DNA Synthesis as Revealed in Structural and Molecular Modeling Studies

DNA adducts, which block replicative DNA polymerases (DNAPs), are often bypassed by lesion-bypass DNAPs, which are mostly in the Y-Family. Y-Family DNAPs can do non-mutagenic or mutagenic dNTP insertion, and understanding this difference is important, because mutations transform normal into tumorige...

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Detalles Bibliográficos
Autores principales: Chandani, Sushil, Jacobs, Christopher, Loechler, Edward L.
Formato: Texto
Lenguaje:English
Publicado: SAGE-Hindawi Access to Research 2010
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2945684/
https://www.ncbi.nlm.nih.gov/pubmed/20936174
http://dx.doi.org/10.4061/2010/784081

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2945684/
https://www.ncbi.nlm.nih.gov/pubmed/20936174
http://dx.doi.org/10.4061/2010/784081

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