The Plk1 Inhibitor BI 2536 Temporarily Arrests Primary Cardiac Fibroblasts in Mitosis and Generates Aneuploidy In Vitro

BI 2536 is a new anti-mitotic drug that targets polo-like kinase 1 (Plk1) and is currently under clinical development for cancer therapy. The effect of this drug on cancer cells has been extensively investigated, but information about the effects on primary dividing cells and differentiated non-divi...

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Detalles Bibliográficos
Autores principales: Lu, Bo, Mahmud, Hasan, Maass, Alexander H., Yu, Bo, van Gilst, Wiek H., de Boer, Rudolf A., Silljé, Herman H. W.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2010
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2945759/
https://www.ncbi.nlm.nih.gov/pubmed/20886032
http://dx.doi.org/10.1371/journal.pone.0012963

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2945759/
https://www.ncbi.nlm.nih.gov/pubmed/20886032
http://dx.doi.org/10.1371/journal.pone.0012963

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