Cargando…

The Plk1 Inhibitor BI 2536 Temporarily Arrests Primary Cardiac Fibroblasts in Mitosis and Generates Aneuploidy In Vitro

BI 2536 is a new anti-mitotic drug that targets polo-like kinase 1 (Plk1) and is currently under clinical development for cancer therapy. The effect of this drug on cancer cells has been extensively investigated, but information about the effects on primary dividing cells and differentiated non-divi...

Descripción completa

Detalles Bibliográficos
Autores principales:	Lu, Bo, Mahmud, Hasan, Maass, Alexander H., Yu, Bo, van Gilst, Wiek H., de Boer, Rudolf A., Silljé, Herman H. W.
Formato:	Texto
Lenguaje:	English
Publicado:	Public Library of Science 2010
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2945759/ https://www.ncbi.nlm.nih.gov/pubmed/20886032 http://dx.doi.org/10.1371/journal.pone.0012963

Ejemplares similares

Regulation of the (pro)renin–renin receptor in cardiac remodelling
por: Mahmud, Hasan, et al.
Publicado: (2012)

Early and late effects of the DPP-4 inhibitor vildagliptin in a rat model of post-myocardial infarction heart failure
por: Yin, Meimei, et al.
Publicado: (2011)

AKIP1, a Cardiac Hypertrophy Induced Protein that Stimulates Cardiomyocyte Growth via the Akt Pathway
por: Yu, Hongjuan, et al.
Publicado: (2013)

The dual role of BI 2536, a small-molecule inhibitor that targets PLK1, in induction of apoptosis and attenuation of autophagy in neuroblastoma cells
por: Li, Zhiheng, et al.
Publicado: (2020)

Phosphorylation by Cdk1 induces Plk1-mediated vimentin phosphorylation during mitosis
por: Yamaguchi, Tomoya, et al.
Publicado: (2005)

BI 2536 induces gasdermin E-dependent pyroptosis in ovarian cancer
por: Huo, Jianting, et al.
Publicado: (2022)

BI2536 induces mitotic catastrophe and radiosensitization in human oral cancer cells
por: Cheng, Chieh-Yuan, et al.
Publicado: (2018)

Heart failure-associated anemia: bone marrow dysfunction and response to erythropoietin
por: Ruifrok, Willem-Peter T., et al.
Publicado: (2010)

Pharmacological inhibition of Polo-like kinase 1 (PLK1) by BI-2536 decreases the viability and survival of hamartin and tuberin deficient cells via induction of apoptosis and attenuation of autophagy
por: Valianou, Matthildi, et al.
Publicado: (2015)

AKIP1 Expression Modulates Mitochondrial Function in Rat Neonatal Cardiomyocytes
por: Yu, Hongjuan, et al.
Publicado: (2013)

Molecular dynamics of PLK1 during mitosis
por: Schmucker, Stephane, et al.
Publicado: (2014)

Multiple Roles of PLK1 in Mitosis and Meiosis
por: Kalous, Jaroslav, et al.
Publicado: (2023)

LXRα improves myocardial glucose tolerance and reduces cardiac hypertrophy in a mouse model of obesity-induced type 2 diabetes
por: Cannon, Megan V., et al.
Publicado: (2015)

Cardiac Function and Architecture Are Maintained in a Model of Cardiorestricted Overexpression of the Prorenin-Renin Receptor
por: Mahmud, Hasan, et al.
Publicado: (2014)

BI-2536 and BI-6727, dual Polo-like kinase/bromodomain inhibitors, effectively reactivate latent HIV-1
por: Gohda, Jin, et al.
Publicado: (2018)

Cyclical stretch induces structural changes in atrial myocytes
por: De Jong, Anne Margreet, et al.
Publicado: (2013)

BI-2536 Promotes Neuroblastoma Cell Death via Minichromosome Maintenance Complex Components 2 and 10
por: Hsieh, Chiao-Hui, et al.
Publicado: (2021)

Emerging role of liver X receptors in cardiac pathophysiology and heart failure
por: Cannon, Megan V., et al.
Publicado: (2015)

Regulatory functional territory of PLK-1 and their substrates beyond mitosis
por: Kumar, Shiv, et al.
Publicado: (2017)

Plk1 regulates mitotic Aurora A function through βTrCP-dependent degradation of hBora
por: Chan, Eunice H. Y., et al.
Publicado: (2008)

A Kinase Interacting Protein 1 (AKIP1) promotes cardiomyocyte elongation and physiological cardiac remodelling
por: Nijholt, Kirsten T., et al.
Publicado: (2023)

Regulation of NDR1 activity by PLK1 ensures proper spindle orientation in mitosis
por: Yan, Maomao, et al.
Publicado: (2015)

PLK1 phosphorylation of pericentrin initiates centrosome maturation at the onset of mitosis
por: Lee, Kwanwoo, et al.
Publicado: (2011)

Recent Progress on the Localization of PLK1 to the Kinetochore and Its Role in Mitosis
por: Kim, Taekyung
Publicado: (2022)

The erythropoietin receptor expressed in skeletal muscle is essential for mitochondrial biogenesis and physiological exercise
por: Nijholt, Kirsten T., et al.
Publicado: (2021)

Observation of D$_{s}^{** }$(2536) meson production by neutrinos in BEBC
por: Asratyan, A E, et al.
Publicado: (1993)

Telomere biology in healthy aging and disease
por: Oeseburg, Hisko, et al.
Publicado: (2009)

Polθ is phosphorylated by PLK1 to repair double-strand breaks in mitosis
por: Gelot, Camille, et al.
Publicado: (2023)

Observation of the decays $ {B}_{(s)}^0 $ → D$_{s1}$(2536)$^{∓}$K$^{±}$
por: Aaij, Roel, et al.
Publicado: (2023)

D+_s1(2536) Production in Hadronic Z0 Decays
por: CERN. Geneva
Publicado: (1996)

Renal Handling of Galectin‐3 in the General Population, Chronic Heart Failure, and Hemodialysis
por: Meijers, Wouter C., et al.
Publicado: (2014)

CDK1 and PLK1 coordinate the disassembly and reassembly of the nuclear envelope in vertebrate mitosis
por: de Castro, Ines J, et al.
Publicado: (2017)

DNA Replication Determines Timing of Mitosis by Restricting CDK1 and PLK1 Activation
por: Lemmens, Bennie, et al.
Publicado: (2018)

Phosphorylation of LSD1 by PLK1 promotes its chromatin release during mitosis
por: Peng, Bin, et al.
Publicado: (2017)

UBAP2L‐dependent coupling of PLK1 localization and stability during mitosis
por: Guerber, Lucile, et al.
Publicado: (2023)

BI2536, a potent and selective inhibitor of polo-like kinase 1, in combination with cisplatin exerts synergistic effects on gastric cancer cells
por: Lian, Guodong, et al.
Publicado: (2018)

Polo‑like kinase 1 selective inhibitor BI2536 (dihydropteridinone) disrupts centrosome homeostasis via ATM‑ERK cascade in adrenocortical carcinoma
por: Lin, Ruei-Ci, et al.
Publicado: (2023)

Galectin-3 and Blood Group: Binding Properties, Effects on Plasma Levels, and Consequences for Prognostic Performance
por: Pozder, Carolin, et al.
Publicado: (2023)

Animal models of cardiorenal syndrome: a review
por: Szymanski, Mariusz K., et al.
Publicado: (2011)

Usp16 regulates kinetochore localization of Plk1 to promote proper chromosome alignment in mitosis
por: Zhuo, Xiaolong, et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_imrqv3041ij2iu4789csu51rpl