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Interactions of Attenuated Mycobacterium tuberculosis phoP Mutant with Human Macrophages

BACKGROUND: Mycobacterium tuberculosis phoP mutant SO2 derived from a clinical isolate was shown to be attenuated in mouse bone marrow-derived macrophages and in vivo mouse infection model and has demonstrated a high potential as attenuated vaccine candidate against tuberculosis. METHODOLOGY/PRINCIP...

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Detalles Bibliográficos
Autores principales: Ferrer, Nadia L., Gomez, Ana B., Neyrolles, Olivier, Gicquel, Brigitte, Martin, Carlos
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2945763/
https://www.ncbi.nlm.nih.gov/pubmed/20885976
http://dx.doi.org/10.1371/journal.pone.0012978