Methylglyoxal Alters the Function and Stability of Critical Components of the Protein Quality Control

BACKGROUND: Increased production and accumulation of methylglyoxal (MGO), as well as increased modification of proteins by glycoxidation, are hallmarks of aging and diabetes. MGO was shown to modify proteins and to contribute to the accumulation of damaged proteins that can be toxic to cells. Howeve...

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Detalles Bibliográficos
Autores principales: Bento, Carla Figueira, Marques, Filipa, Fernandes, Rosa, Pereira, Paulo
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2010
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2945773/
https://www.ncbi.nlm.nih.gov/pubmed/20885985
http://dx.doi.org/10.1371/journal.pone.0013007

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2945773/
https://www.ncbi.nlm.nih.gov/pubmed/20885985
http://dx.doi.org/10.1371/journal.pone.0013007

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