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Methylglyoxal Alters the Function and Stability of Critical Components of the Protein Quality Control
BACKGROUND: Increased production and accumulation of methylglyoxal (MGO), as well as increased modification of proteins by glycoxidation, are hallmarks of aging and diabetes. MGO was shown to modify proteins and to contribute to the accumulation of damaged proteins that can be toxic to cells. Howeve...
| Autores principales: | , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2010
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2945773/ https://www.ncbi.nlm.nih.gov/pubmed/20885985 http://dx.doi.org/10.1371/journal.pone.0013007 |