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Trop2 expression contributes to tumor pathogenesis by activating the ERK MAPK pathway
BACKGROUND: Trop2 is a cell-surface glycoprotein overexpressed by a variety of epithelial carcinomas with reported low to restricted expression in normal tissues. Expression of Trop2 has been associated with increased tumor aggressiveness, metastasis and decreased patient survival, but the signaling...
| Autores principales: | , , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
BioMed Central
2010
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2946292/ https://www.ncbi.nlm.nih.gov/pubmed/20858281 http://dx.doi.org/10.1186/1476-4598-9-253 |